PD-L1&HVEM Dual aAPC Cell
CBP74683
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| I. Background | |
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PD-L1与HVEM是两种重要的免疫检查点分子，在肿瘤免疫逃逸中各自发挥作用，且多项研究显示二者在非小细胞肺癌等肿瘤中的表达常呈负相关，提示它们可能代表互补的免疫抑制机制。 |
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| II. Description | |
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PD-L1&HVEM Dual aAPC Cell 报告基因药靶模型很好的模拟了体内 PD-L1&HVEM 的信号转导过程。 |
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| III. Introduction | |
| Expressed gene: | PD-L1&HVEM |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K + 10% FBS + 600 μg/ml Hygromycin B + 3 μg/ml Puromycin + 5 μg/ml Blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
IV. Representative Data Figure 1. Dose Response of Blocking Antibodies in PD-1&BTLA Dual Effector Reporter Cell(C59) with PD-L1&HVEM Dual aAPC Cell(C18). |
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