GCGR COS7
CBP71670
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索取Protocol
产品描述
产品数据库
| I. Background | |
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GCGR（胰高血糖素受体）是B类G蛋白偶联受体，主要在肝脏和肾脏中表达，顺利获得结合胰高血糖素激活腺苷酸环化酶，促进肝糖原分解和糖异生，是维持血糖稳态的核心分子。 |
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| II. Description | |
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GCGR COS7细胞药靶模型很好的模拟了体内 GCGR的信号转导过程 。 |
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| III. Introduction | |
| Expressed gene: | GCGR |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM + 10%FBS + 2μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional assay for GCGR |
| Transducer: | Gs |
IV. Representative Data Figure 1. Recombinant GCGR COS7 stably expressing GCGR.  Figure 2. HTRF cAMP Assay with GCGR COS7(C40). |
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